Abstract: In order to ensure the normal development of transportation and production activities, we must do well in the maintenance and management of the relevant mobile transport equipment, so as to ensure the advanced nature of the mobile transport equipment and help the actual production activities. In order to ensure the effective development of the maintenance and management of the motor transport equipment, it is necessary to carry out the maintenance management work of the motor transport equipment in combination with the problems of the frequent failures of the motor transport equipment and the location of the frequent failures. Based on this, this paper focuses on the application of targeted maintenance management in the management of mechanical equipment, in order to play a certain reference for the development of mechanical equipment management.