Abstract: The application of engineering intelligent mechanical equipment in building construction has greatly promoted the development of the automation industry, improved the production environment of the industry, reduced manpower and material resources, and improved industrial production efficiency and production quality. Based on this, this article takes engineering intelligent mechanical equipment as the research object, and proposes its application strategy in the construction of prefabricated prefabricated buildings. The research shows that its application is of great significance to promote the development of prefabricated buildings.