Abstract: In recent years, as the population of our country continues to increase, the pace of urbanization is accelerating, in order to save the use of building area, there are more and more high-rise buildings in our country. Due to the architectural characteristics of high-rise buildings and the use of a large number of combustible materials in construction, and there are a large number of lines in the interior, which makes the high-rise buildings have greater security risks, it is easy to cause fire accidents. Therefore, people put forward higher requirements for fire protection design in high-rise buildings. This paper analyzes and studies the application of performance-based design methods in high-rise building fire protection, in order to improve the fire safety factor of high-rise buildings.