Abstract: The machinery industry is a national pillar industry, and whether machinery and equipment management is in place will directly affect the development of the entire industry. In the production of enterprises, mechanical processing equipment is an important equipment to ensure the output and quality of enterprises. With the continuous increase of types, specifications and models of mechanical processing equipment, how to use mechanical processing equipment reasonably becomes the key. To this end, this article first elaborated the management of mechanical processing equipment, and on this basis, put forward the corresponding management countermeasures and safeguards,with a view to comprehensively enhance the market competitiveness of enterprises.