Abstract: At present, in order to effectively alleviate the shortage of land resources, building structures are showing a trend of high-rise development. The emergence of high-rise and super high-rise buildings eff ectively realizes the rational use of underground and above-ground space resources. However, because of the large height of high-rise buildings, the requirements for structural design are relatively high. Therefore, in order to achieve optimal seismic design, professional designers must start from a comprehensive perspective and adopt appropriate design methods. Based on this, this article focuses on the analysis of the seismic design infl uencing factors and design strategies in the structural design of high-rise buildings for reference.