Abstract: With the development of big data and Internet of Things technology, manufacturing enterprises have put forward higher requirements for optimal allocation of industrial resources, and the integration of factory informatization and industrialization has become an irresistible trend. In this context, digital twin technology emerges as the times require. It not only provides necessary technical support for the construction of wisdow factories, but also helps factories make correct decisions in product design, production and manufacturing, which is the key to the realization of wisdow factories. This paper introduces the concepts related to digital twin and wisdow factory, puts forward the construction framework of digital twin wisdow factory, and applies it to practical cases. Practice proves that it can maximize the production benefit of the factory and is worth promoting.