Abstract: In recent years, the level of social and economic development in my country has been continuously improved, which has led to great progress in construction technology, and more and more high-rise buildings with complex structures have appeared. In the real estate industry, especially in residential quarters and public buildings, large chassis with multi-tower structures have emerged in large numbers, with more and more towers and larger chassis. The structural design of large-chassis and multi-tower building is complex, and how to design an economical and safe combined structure is an important issue faced by designers. Based on this, the application of the large-chassis multi-tower structure in high-rise buildings was studied, the coordination, diversity and irregularity of the multi-tower structure were analyzed, combined with the actual situation of high-rise buildings, and reasonable The design points have improved the design level of the multi-tower structure.