Abstract: In order to promote the construction process of urban high-rise building fire safety system, reduce the probability of high-rise building fire accidents, and protect the property and life safety of high-rise building users. The fire department should focus on the fire supervision and inspection of high-rise buildings, deeply understand the practical significance of fire supervision and inspection to the stable operation of high-rise buildings, and sort out and summarize the objective difficulties in fire supervision and inspection. Based on this, This paper analyzes the difficulties and key points of fire prevention supervision and inspection of urban high-rise buildings, and puts forward the improvement measures of fi re prevention supervision and inspection of urban high-rise buildings, for reference.