Abstract: The hospital has the characteristics of crowd concentration and large flow of people,and various advanced medical equipment has higher requirements for the working environment. When central air conditioning in hospital provides comfortable medical and working environment for patients and medical staff, it also has problems such as long running time of refrigeration unit, high power of circulating water pump and serious energy consumption. In response to the call of the state, hospital central air conditioning system can adopt relevant energy-saving technology, in order to achieve the purpose of energy saving and consumption reduction. Based on this, combined with the actual situation of the hospital, starting from the principle of central air conditioning system,this paper deeply explores the energysaving technology of central air-conditioning in modern hospitals in the new era.